pentobarbital will reduce the extent or result of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the extent or outcome of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Keep track of.Induction of microsomal enzymes by this drug, may shorten the 50 %-life of doxycycline for so